100
100
"environmental residuals"!}
101
101
\item{pgresidualY}{Environmental residuals from analysis,
102
102
based on covariate effects and predicted breeding value.
103
} \item{grresidualY}{GRAMMAR-transform trait
104
transformation} \item{grammarGamma}{list with
105
GRAMMAR-gamma correction factors} \item{InvSigma}{Inverse
106
of the variance-covariance matrix, computed at the MLEs
107
-- these are used in \code{\link{mmscore}} and
103
} \item{grresidualY}{GRAMMAR+ transformed trait
104
residuals} \item{grammarGamma}{list with GRAMMAR-gamma
105
correction factors} \item{InvSigma}{Inverse of the
106
variance-covariance matrix, computed at the MLEs -- these
107
are used in \code{\link{mmscore}} and
108
108
\code{\link{grammar}} functions.} \item{call}{The details
109
109
of call} \item{measuredIDs}{Logical values for IDs who
110
110
were used in analysis (traits and all covariates
180
180
# note that procedure runs on CLEAN data
181
require(GenABEL.data)
181
182
data(ge03d2ex.clean)
182
183
gkin <- ibs(ge03d2ex.clean,w="freq")
183
184
h2ht <- polygenic(height ~ sex + age, kin=gkin, ge03d2ex.clean)
203
204
quantitative traits: variance components without matrix
204
205
inversion. Biometrics 46, 399-413.
206
209
Aulchenko YS, de Koning DJ, Haley C. Genomewide rapid
207
210
association using mixed model and regression: a fast and
208
211
simple method for genome-wide pedigree-based quantitative
209
212
trait loci association analysis. Genetics. 2007
212
217
Amin N, van Duijn CM, Aulchenko YS. A genomic background
213
218
based method for association analysis in related
214
219
individuals. PLoS ONE. 2007 Dec 5;2(12):e1274.
216
G. Svischeva et al. (in preparation)
223
Svischeva G, Axenovich TI, Belonogova NM, van Duijn CM,
224
Aulchenko YS. Rapid variance components-based method for
225
whole-genome association analysis. Nature Genetics. 2012
226
44:1166-1170. doi:10.1038/ng.2410
228
for GRAMMAR+ transformation
230
Belonogova NM, Svishcheva GR, van Duijn CM, Aulchenko YS,
231
Axenovich TI (2013) Region-Based Association Analysis of
232
Human Quantitative Traits in Related Individuals. PLoS
233
ONE 8(6): e65395. doi:10.1371/journal.pone.0065395
219
236
\code{\link{polygenic_hglm}}, \code{\link{mmscore}},