3
0.395144 0.123954 5.076149
4
2.489084 0.534551 0.528768 0.062556
5
0.969894 2.807908 1.695752 0.523386 0.084808
6
1.038545 0.363970 0.541712 5.243870 0.003499 4.128591
7
2.066040 0.390192 1.437645 0.844926 0.569265 0.267959 0.348847
8
0.358858 2.426601 4.509238 0.927114 0.640543 4.813505 0.423881 0.311484
9
0.149830 0.126991 0.191503 0.010690 0.320627 0.072854 0.044265 0.008705 0.108882
10
0.395337 0.301848 0.068427 0.015076 0.594007 0.582457 0.069673 0.044261 0.366317 4.145067
11
0.536518 6.326067 2.145078 0.282959 0.013266 3.234294 1.807177 0.296636 0.697264 0.159069 0.137500
12
1.124035 0.484133 0.371004 0.025548 0.893680 1.672569 0.173735 0.139538 0.442472 4.273607 6.312358 0.656604
13
0.253701 0.052722 0.089525 0.017416 1.105251 0.035855 0.018811 0.089586 0.682139 1.112727 2.592692 0.023918 1.798853
14
1.177651 0.332533 0.161787 0.394456 0.075382 0.624294 0.419409 0.196961 0.508851 0.078281 0.249060 0.390322 0.099849 0.094464
15
4.727182 0.858151 4.008358 1.240275 2.784478 1.223828 0.611973 1.739990 0.990012 0.064105 0.182287 0.748683 0.346960 0.361819 1.338132
16
2.139501 0.578987 2.000679 0.425860 1.143480 1.080136 0.604545 0.129836 0.584262 1.033739 0.302936 1.136863 2.020366 0.165001 0.571468 6.472279
17
0.180717 0.593607 0.045376 0.029890 0.670128 0.236199 0.077852 0.268491 0.597054 0.111660 0.619632 0.049906 0.696175 2.457121 0.095131 0.248862 0.140825
18
0.218959 0.314440 0.612025 0.135107 1.165532 0.257336 0.120037 0.054679 5.306834 0.232523 0.299648 0.131932 0.481306 7.803902 0.089613 0.400547 0.245841 3.151815
19
2.547870 0.170887 0.083688 0.037967 1.959291 0.210332 0.245034 0.076701 0.119013 10.649107 1.702745 0.185202 1.898718 0.654683 0.296501 0.098369 2.188158 0.189510 0.249313
21
0.079066 0.055941 0.041977 0.053052 0.012937 0.040767 0.071586 0.057337 0.022355 0.062157 0.099081 0.064600 0.022951 0.042302 0.044040 0.061197 0.053287 0.012066 0.034155 0.069147
23
A R N D C Q E G H I L K M F P S T W Y V
24
Ala Arg Asn Asp Cys Gln Glu Gly His Ile Leu Lys Met Phe Pro Ser Thr Trp Tyr Val
26
Symmetrical part of the rate matrix and aa frequencies,
27
estimated from 3905 globular protein amino acid sequences forming 182
29
The first part above indicates the symmetric 'exchangeability'
30
parameters, where s_ij = s_ji. The s_ij above are not scaled, but the
31
PAML package will perform this scaling.
32
The second part gives the amino acid frequencies (pi_i)
33
estimated from the 3905 sequences. The net replacement rate from i to
34
j is Q_ij = s_ij*pi_j.
39
Le, S. Q., and O. Gascuel. 2008. An improved general amino acid replacement matrix. Mol. Biol. Evol. 25:1307-1320.