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Partial Order Alignment for multiple sequence alignment
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Some information about t-coffee from the Debian-Med project.
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POA is Partial Order Alignment, a fast program for multiple sequence
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alignment (MSA) in bioinformatics. Its advantages are speed,
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scalability, sensitivity, and the superior ability to handle branching
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/ indels in the alignment. Partial order alignment is an approach to
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MSA, which can be combined with existing methods such as progressive
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alignment. POA optimally aligns a pair of MSAs and which therefore can
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be applied directly to progressive alignment methods such as CLUSTAL.
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For large alignments, Progressive POA is 10-30 times faster than
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CLUSTALW. POA is published in Bioinformatics. 2004 Jul
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Homepage: http://www.bioinformatics.ucla.edu/poa