1
ID MA32_HUMAN STANDARD; PRT; 282 AA.
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DT 01-FEB-1995 (Rel. 31, Created)
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DT 01-FEB-1995 (Rel. 31, Last sequence update)
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DE COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, MITOCHONDRIAL
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DE PRECURSOR (GLYCOPROTEIN GC1QBP) (GC1Q-R PROTEIN) (HYALURONAN-BINDING
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DE PROTEIN 1) (PRE-MRNA SPLICING FACTOR SF2, P32 SUBUNIT) (P33).
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KW Mitochondrion; Transit peptide; 3D-structure.
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OS Homo sapiens (Human).
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RP SEQUENCE FROM N.A., AND SEQUENCE OF 74; 76-93 AND 208-216.
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RA Honore B., Madsen P., Rasmussen H.H., Vandekerckhove J., Celis J.E.,
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RT "Cloning and expression of a cDNA covering the complete coding region
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RT of the P32 subunit of human pre-mRNA splicing factor SF2.";
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RL Gene 134:283-287(1993).
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RP SEQUENCE OF 5-282 FROM N.A., AND SEQUENCE OF 74-114.
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RA Krainer A.R., Mayeda A., Kozak D., Binns G.;
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RT "Functional expression of cloned human splicing factor SF2: homology
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RT to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.";
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RL Cell 66:383-394(1991).
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RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
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RA Ghebrehiwet B., Lim B.L., Peerschke E.I., Willis A.C., Reid K.B.;
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RT "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface
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RT glycoprotein that binds to the globular 'heads' of C1q.";
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RL J. Exp. Med. 179:1809-1821(1994).
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RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
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RA Jiang J., Zhang Y., Krainer A.R., Xu R.-M.;
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RT "Crystal structure of human p32, a doughnut-shaped acidic
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RT mitochondrial matrix protein.";
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RL Proc. Natl. Acad. Sci. U.S.A. 96:3572-3577(1999).
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DR EMBL; L04636; AAA16315.1; -. EMBL; M69039; AAA73055.1; -. EMBL;
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DR X75913; CAA53512.1; -. PIR; JT0762; JT0762. PIR; S44104; S44104. PDB;
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DR 1P32; 06-APR-99. MIM; 601269; -.
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CC -!- FUNCTION: NOT KNOWN. BINDS TO THE GLOBULAR "HEADS" OF C1Q THUS
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CC INHIBITING C1 ACTIVATION.
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CC -!- SUBCELLULAR LOCATION: MITOCHONDRIAL MATRIX.
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CC -!- SIMILARITY: BELONGS TO THE MAM33 FAMILY.
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CC -!- CAUTION: WAS ORIGINALLY (REF.1 AND REF.2) THOUGHT TO BE A PRE-MRNA
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CC SPLICING FACTOR THAT PLAYS A ROLE IN PREVENTING EXON SKIPPING,
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CC ENSURING THE ACCURACY OF SPLICING AND REGULATING ALTERNATIVE
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CC ----------------------------------------------------------------------
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CC This SWISS-PROT entry is copyright. It is produced through a collabora
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CC between the Swiss Institute of Bioinformatics and the EMBL outstati
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CC the European Bioinformatics Institute. There are no restrictions on
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CC use by non-profit institutions as long as its content is in no
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CC modified and this statement is not removed. Usage by and for commer
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CC entities requires a license agreement (See http://www.isb-sib.ch/annou
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or send an email to license@isb-sib.ch).
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MA32_HUMAN Length: 282 October 20, 2010 20:08:40 Type: N Check: 6672 ..
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1 MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA
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51 GSERRPGLLR PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK
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101 TLPKMSGGWE LELNGTEAKL VRKVAGEKIT VTFNINNSIP PTFDGEEEPS
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151 QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK ALVLDCHYPE DEVGQEDEAE
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201 SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM DFLADRGVDN
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251 TFADELVELS TALEHQEYIT FLEDLKSFVK SQ